Protein Sequences Recapitulate Genetic Code Evolution
نویسندگان
چکیده
منابع مشابه
Protein evolution with an expanded genetic code.
We have devised a phage display system in which an expanded genetic code is available for directed evolution. This system allows selection to yield proteins containing unnatural amino acids should such sequences functionally outperform ones containing only the 20 canonical amino acids. We have optimized this system for use with several unnatural amino acids and provide a demonstration of its ut...
متن کاملUsing the Genetic Code Wisdom for Recognizing Protein Coding Sequences
We have elaborated a new method of recognizing protein coding sequences in genomic sequences. The method is exploiting a specific way of genetic code degeneration and relations between mutational pressure and selection pressure shaping the amino acid usage in the proteomes. It is based on analyses of correlations in nucleotide occurrence separately in the first, the second and the third putativ...
متن کاملProtein evolution drives the evolution of the genetic code and vice versa.
A model for the developmental pathway of the genetic code, grounded on group theory and the thermodynamics of codon-anticodon interaction is presented. At variance with previous models, it takes into account not only the optimization with respect to amino acid attributes but, also physicochemical constraints and initial conditions. A 'simple-first' rule is introduced after ranking the amino aci...
متن کاملCollective evolution and the genetic code.
A dynamical theory for the evolution of the genetic code is presented, which accounts for its universality and optimality. The central concept is that a variety of collective, but non-Darwinian, mechanisms likely to be present in early communal life generically lead to refinement and selection of innovation-sharing protocols, such as the genetic code. Our proposal is illustrated by using a simp...
متن کاملAlgebraic Evolution of the Genetic Code
The evolution of the genetic code has been speculated by many authors, but all of them lack determinative proofs. Jukes [4] inferred the evolution from mitochondrial codes, which are different from the universal codes in some respects. He postulated an archetypal code containing 14 amino acids, from which the universal code could evolve by gene duplication followed by mutational changes. This p...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Computational and Structural Biotechnology Journal
سال: 2018
ISSN: 2001-0370
DOI: 10.1016/j.csbj.2018.05.001